From the north
Take the A1 motorway from Florence towards Rome, leave the motorway at the Valdichiana/Bettolle exit, follow the signs for Torrita di Siena and then Pienza.
From the south
Take the A1 motorway from Rome towards Florence, leave the motorway at the Chiusi/Chianciano Terme exit, take the SS 146 to Chianciano Terme then proceed towards Montepulciano and then Pienza.
Take the SS 2 Cassia until you get to San Quirico d’Orcia, then take the SS 146 to Pienza.